http://www.nucleushealth.com/ - This narrated 3D medical animation illustrates the story of a heart attack (myocardial infarction) from a blocked coronary artery due to atherosclerosis, which is chronic inflammation of the blood vessels. Beginning with damage to the endothelial arterial wall, the animation shows how a white blood cell entering the wall of the artery differentiates (changes) into a macrophage, grabbing and digesting cholesterol. As the cell does its job, it transforms into a foam cell, which, unfortunately, becomes part of the plaque within the blood vessel wall. Ultimately, over a period of years, the plaque grows and ruptures the blood vessel wall, spilling into the blood stream and eventually blocking the left anterior descending coronary artery (LAD) supplying the left ventricle. The animation ends showing an external view of the heart with dark area representing the death of the ventricle wall.
#Atherosclerosis #HeartAttack #Heart ANS00260
Content
21.44 -> atherosclerosis is a life-threatening
disease
24.59 -> that may have begun to develop during
childhood
28.2 -> this condition is a process in which deposits of fatty material,
31.73 -> call plaque, build up inside the walls
of arteries
35.33 -> reducing, or completely blocking, blood flow.
38.69 -> although the exact causes of atherosclerosis are not clear
42.42 -> many scientists think it begins with
damage to the inner wall of an artery,
46.98 -> called the endothelium. Substances
traveling in the blood,
50.989 -> such as cholesterol, fats, and cellular
waste products,
55.28 -> keenly inside the damaged area and the
arterial wall when chemical reactions
60.94 -> occurring within the build-up of
material
63.1 -> cause cholesterol molecules oxidized
this initiates an inflammatory response
69.66 -> in which the ended delial cells at the
damage side
73.13 -> release chemicals that signal call for
help
76.14 -> on in response monocytes bloodstream
80.67 -> travel to the damage site ruled
stimulation from
84.8 -> oxidized cholesterol converge the
monocytes
88.009 -> into macrophages who the macrophages
91.86 -> eat and digest the cholesterol molecules
all
95.55 -> as a result of this process the
macrophages change into bone cells
100.5 -> which accumulate to form plaque for
103.58 -> as the black increases in size the
arterial wall
107.02 -> thickens and hardens on
112.17 -> on and
116.6 -> at the same time smooth muscle cells
within the arterial wall
120.869 -> begin to multiply the
137.36 -> and
139.09 -> most the smooth muscle cells moved to
the service at the plaque
142.7 -> the cells contribute to the formation
146.37 -> affirmed by Bruce Campbell covering the
plaque
149.5 -> then surely the passageway through the
artery near
153.9 -> this enough to reduce blood flow and the
amount of oxygen received other organs
158.73 -> it supplies
159.67 -> on overtime the cat may erode
162.95 -> and break open releasing plaque into the
bloodstream
166.569 -> the plaque can flow downstream
169.79 -> and contribute to the whole nation to
like which can stop like
175 -> as a result limited blood supplies
available to the area surrounding the
179.4 -> partially blocked artery
180.89 -> degrading and potentially killing the
neighboring tissue
