#Pioglitazone | Uses, Dosage, Side Effects & Mechanism | Actos

Aug 26, 2023

#Pioglitazone | Uses, Dosage, Side Effects & Mechanism | Actos

Pioglitazone is a thiazolidinedione used adjunctively with diet and exercise to normalize glycemic levels in adults with type 2 diabetes mellitus.

In this video, let’s find found:
What is Pioglitazone?
What is Pioglitazone used for?
Contraindication
What are the side effects of taking Pioglitazone?
How does Pioglitazone work?
How to use Pioglitazone?

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Content

0.16 -> Pioglitazone is a thiazolidinedione used adjunctively with diet and exercise to normalize glycemic

6.17 -> levels in adults with type 2 diabetes mellitus.

10.519 -> In this video, let’s find found: What is Pioglitazone?

13.96 -> What is Pioglitazone used for?

18.97 -> Contraindication What are the side effects of taking Pioglitazone?

23.42 -> How does Pioglitazone work?

25.81 -> How to use Pioglitazone?

32.18 -> What is Pioglitazone?

33.18 -> Pioglitazone, sold under the brand name Actos among others, is an anti-diabetic medication

37.489 -> used to treat type 2 diabetes.

40.65 -> It may be used with metformin, a sulfonylurea, or insulin.

45.59 -> Use is recommended together with exercise and diet.

49.7 -> It is not recommended in type 1 diabetes.

52.289 -> It is taken by mouth.

54.91 -> Pioglitazone was patented in 1985, and came into medical use in 1999.

61.88 -> It is available as a generic medication.

65.08 -> In 2020, it was the 168th most commonly prescribed medication in the United States, with more

71.58 -> than 3 million prescriptions.

74.479 -> It was withdrawn in France and Germany in 2011.

79.659 -> What is Pioglitazone used for?

81.49 -> Pioglitazone is indicated as an adjunct to diet and exercise to improve glycemic control

87.39 -> in adults with type 2 diabetes mellitus.

91.15 -> It is also available in combination with metformin, glimepiride, or alogliptin for the same indication.

100.59 -> Contraindication Pioglitazone cannot be used in patients with

104.159 -> a known hypersensitivity to pioglitazone, other thiazolidinediones or any of components

109.74 -> of its pharmaceutical forms.

111.52 -> It is ineffective and possibly harmful in diabetes mellitus type 1 and diabetic ketoacidosis.

118.43 -> Its safety in pregnancy, lactation (breastfeeding) and people under 18 is not established.

125.58 -> Given previous experiences with the related drug troglitazone, acute diseases of the liver

131.48 -> are regarded as a contraindication for pioglitazone.

137.79 -> Side effects Common side effects include headaches, muscle

142.099 -> pains, inflammation of the throat, and swelling.

145.95 -> Serious side effects may include bladder cancer, low blood sugar, heart failure, and osteoporosis.

153.28 -> Use is not recommended in pregnancy or breastfeeding.

157.16 -> It is in the thiazolidinedione (TZD) class and works by improving sensitivity of tissues

163.099 -> to insulin.

165.03 -> Pharmacodynamic Pioglitazone enhances cellular responsiveness

169.709 -> to insulin, increases insulin-dependent glucose disposal, and improves impaired glucose homeostasis.

177.1 -> In patients with type 2 diabetes mellitus, these effects result in lower plasma glucose

182.93 -> concentrations, lower plasma insulin concentrations, and lower HbA1c values.

189.04 -> Significant fluid retention leading to the development/exacerbation of congestive heart

193.83 -> failure has been reported with pioglitazone - avoid its use in patients in heart failure

198.879 -> or at risk of developing heart failure.

202.08 -> There is some evidence that pioglitazone may be associated with an increased risk of developing

206.849 -> bladder cancer.

208.39 -> Pioglitazone should not be used in patients with active bladder cancer and should be used

213.629 -> with caution in patients with a history of bladder cancer.

217.659 -> Mechanism of action Pioglitazone is a selective agonist at peroxisome

222.989 -> proliferator-activated receptor-gamma (PPARγ) in target tissues for insulin action such

228.39 -> as adipose tissue, skeletal muscle, and liver.

231.93 -> Activation of PPARγ increases the transcription of insulin-responsive genes involved in the

237.33 -> control of glucose and lipid production, transport, and utilization.

241.799 -> Through this mechanism, pioglitazone both enhances tissue sensitivity to insulin and

247.569 -> reduces the hepatic production of glucose (i.e. gluconeogenesis) - insulin resistance

252.84 -> associated with type 2 diabetes mellitus is therefore improved without an increase in

257.69 -> insulin secretion by pancreatic beta cells.

262.049 -> Half-life The mean serum half-life of pioglitazone and

265.699 -> its metabolites (M-III and M-IV) range from 3-7 hours and 16-24 hours, respectively.

274.259 -> Dose Type 2 Diabetes Mellitus

278.52 -> Indicated as monotherapy or with insulin or insulin secretagogues

281.889 -> 15-30 mg PO with meal qDay initial; may increase dose by 15 mg with careful monitoring to 45

291.139 -> mg qDay maximum Monitor ALT at start of treatment, qMonth

296.09 -> for 12 months, q3Months thereafter

301.699 -> Safety advice Pioglitazone is not recommended in pregnancy

306.009 -> as there is not much information about its safety during pregnancy.

310.479 -> Other medicines used to treat diabetes, such as insulin and metformin, are safe to take

315.49 -> while pregnant.

318.08 -> That’s all the information about Pioglitazone we collected.

323.92 -> Thanks for listening!

325.16 -> Do not forget to like, share and subscribe for the He-info channel if you like this video

330.759 -> to update more Health information!

Source: https://www.youtube.com/watch?v=vnPkBKuyo-I