What is Coronary Artery Disease (CAD) - Causes and Consequences
What is Coronary Artery Disease (CAD) - Causes and Consequences
Coronary Artery Disease is characterized by atherosclerotic plaque formation in the coronary arteries and underlies ischaemic heart disease, the leading cause of death worldwide. More Details at https://www.thrombosisadviser.com/en/…
Rupture of an atherosclerotic plaque can lead to the formation of a blood clot in the artery. This is known as atherothrombosis and can lead to restricted blood flow through the artery, potentially causing myocardial infarction. Although antiplatelet therapy is available to patients with CAD, the residual risk of atherothrombotic events remains high.
Approval Number: G.MKT.GM.XA.08.2017.1694
Content
2.74 -> More than 6% of adults suffer from ischaemic heart disease,
7.12 -> which results from coronary artery disease – or CAD.
11.83 -> Ischaemic heart disease is the most common single cause of death worldwide.
16.99 -> Atherosclerosis is a systemic disease characterized by the formation of plaques in the arteries.
22.96 -> Depending on the arteries affected this can lead to stroke, myocardial
27.22 -> infarction or acute limb ischaemia. Atherosclerotic plaque formation in the coronary arteries
34.059 -> is characteristic of CAD, a progressive condition that causes restricted blood flow to the heart.
40.18 -> Rupture of one of these plaques can lead to the formation of a blood clot in the lumen of the artery,
44.53 -> known as atherothrombosis.
47.62 -> This blood clot can grow to further limit – or even completely block – blood flow through the artery,
54.489 -> potentially resulting in myocardial infarction.
57.969 -> The degree of stenosis (or narrowing) of the arteries and
62.46 -> characteristics of the plaque determine the symptoms that a patient may experience.
67.3 -> There may be no symptoms until significant stenosis has occurred. Apart from event prevention through lifestyle
74.53 -> modifications such as smoking cessation and dietary changes,
78.6 -> guidelines for the treatment of CAD recommend risk factor management for hypertension, diabetes or dyslipidaemia,
86.38 -> antithrombotic therapy
87.759 -> with antiplatelet agents and, in some cases,
91.27 -> revascularization
92.56 -> using a stent to widen the artery and restore blood flow.
96.7 -> Despite antiplatelet therapy, the residual risk of atherothrombotic events remains high.
102.72 -> In one clinical study, there was a 7% residual risk of stroke, myocardial infarction
108.28 -> or cardiovascular death despite dual antiplatelet treatment in patients with,
113.9 -> or at high risk of, cardiovascular disease.
117.22 -> In another clinical study, dual antiplatelet therapy with ticagrelor and acetylsalicylic acid
123.48 -> in patients with previous myocardial infarction reduced the risk of adverse cardiovascular events,
129.91 -> but increased the risk of bleeding.
132.34 -> Despite this, 8% of patients still experienced adverse cardiovascular events over 3 years.
139.38 -> To help reduce this residual risk,
141.52 -> clinical trials are investigating optimal treatment strategies in patients with CAD.
146.74 -> The results of these studies hold great interest for physicians and patients alike.
160.7 ->
Source: https://www.youtube.com/watch?v=SySIMmg-ars