Mitral-Valve Repair in Heart Failure
Mitral-Valve Repair in Heart Failure
In patients with heart failure, medical therapy and cardiac resynchronization may provide symptomatic relief and, in some patients, lessen the severity of secondary mitral regurgitation, but whether correcting mitral regurgitation improves prognosis is unknown. Read the abstract: https://nej.md/2QQ0jA2
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Content
6.14 -> The Prognosis in patients with heart failure and
secondary mitral regurgitation is poor.
11.11 -> Although surgical mitral valve repair and
replacement have not been shown to reduce
14.57 -> hospitalizations or death, transcatheter mitral
valve repair may improve clinical outcomes.
20.24 -> In this multi-center, randomized, controlled,
open-labelled trial, 614 patients with heart
25.14 -> failure and moderate-to-severe or severe secondary
mitral regurgitation who remained symptomatic
30.66 -> despite maximal medical therapy were randomized
to transcatheter mitral-valve repair,
35.56 -> plus medical therapy or to medical therapy alone.
39.1 -> The primary efficacy end point was all hospitalizations
for heart failure within 24 months.
44.41 -> The primary safety end point was freedom from
device related complications at 12 months.
49.399 -> A key pre-specified secondary end point was
all-cause mortality within 24 months.
54.48 -> The annualized rate of all hospitalizations
for heart failure within 24 months was significantly
59.1 -> lower in the device group than in the
control group.
62 -> At 12 months follow-up, 96.6% of patients
in the intervention group were free of device
67.39 -> related complications, exceeding a prespecified
threshold.
71.22 -> All-cause mortality within 24 months was lower
in the device group than in the control group.
75.99 -> The authors conclude that among patients
with heart failure and moderate-to-severe
79.27 -> or severe secondary mitral regurgitation who
remained symptomatic despite maximal medical
84.1 -> therapy, transcatheter mitral-valve repair may improve clinical outcomes.
89.04 -> Full trial results are available at NEJM.org
Source: https://www.youtube.com/watch?v=R77C2pto-M0