2019 Excellence Award in Hypertension Research
2019 Excellence Award in Hypertension Research
Joey Granger, PhD, immediate past chair of the Council on Hypertension interviews the 2019 Excellence Award for Hypertension Research recipient Rhian Touyz, MBBCh, PhD about her work on the molecular mechanisms and vascular biology of hypertension.
Content
2.959 -> I'm here with dr. towers today and dr.
5.819 -> towers will be receiving the Excellence
8.099 -> Award in hypertension research and this
10.559 -> award is the highest award given by the
12.66 -> Council of hypertension so Rhian
15.289 -> congratulations and tomorrow you'll be
17.94 -> given a lecture on your outstanding
20.189 -> research in addition we'll be
22.47 -> recognizing you with the award at our
24.93 -> awards banquet tomorrow evening so could
27.18 -> you tell us a little bit about what you
28.74 -> can be speaking about in during your
30.779 -> lecture sure Joey
32.279 -> firstly let me say how absolutely
33.87 -> delighted I am to be the recipient of
36.27 -> the 2019 award of research excellence
39.329 -> and hypertension from this council it
41.969 -> means a lot to me knowing who's been
44.34 -> previous recipients and also I feel very
48.239 -> honored and very humbled to be the
50.789 -> recipient of this award I have spent my
54.84 -> professional career studying the
58.59 -> mechanisms of hypertension and in
61.079 -> particular I'm interested in the
62.85 -> molecular mechanisms of hypertension and
65.07 -> related especially to the vascular
68.63 -> changes that occur during the
71.43 -> development of hypertension for many
74.13 -> years we've been studying signal
76.11 -> transduction looking at various
78.03 -> potential signaling pathways that become
80.729 -> aberrant with respect to vascular
82.979 -> changes in hypertension and I started my
86.57 -> research many many years ago looking
90.21 -> initially at the role of cations in the
94.2 -> regulation of aeschylus with our cell
96.36 -> function in the 1970s 1980s changes in
101.579 -> intracellular calcium and sodium were
104.28 -> implicated as being very important in
106.5 -> the regulation of vascular function and
108.689 -> then I started to look at another cation
111.509 -> called magnesium which for various
114.96 -> reasons has actually been considered a
117 -> neglected iron but what we didn't know
120.21 -> about magnesium were the mechanisms that
122.85 -> actually regulated vascular
124.89 -> intracellular magnesium levels and over
127.74 -> the past few years we and many other
129.899 -> labs have focused on understanding
132.93 -> the cation channels particularly the
135.9 -> transient receptor potential may last a
137.97 -> turn six and seven cation channels that
141.36 -> regulate magnesium so I'll be talking a
144.06 -> little bit about the contributions that
146.159 -> we have made in terms of magnesium
149.31 -> homeostasis and the role of triple7 in
152.159 -> vascular pathology and hypertension now
156.54 -> we know that there are many different
158.34 -> signaling pathways that regulate
160.17 -> vascular function and something that's
163.29 -> been quite interesting is that many of
165.389 -> the signaling molecules with a
167.659 -> deregulated contraction dilation map
171.659 -> kinases and cell growth are regulated in
174.54 -> large part by changes in the redox milea
177.659 -> of vascular cells and so a large part of
181.889 -> my research has focused on understanding
184.4 -> the oxidative changes there to regulate
188.48 -> signaling vascular function with a
191.099 -> particular interest on the energy Katoch
193.95 -> seducers that generate reactive oxygen
196.62 -> species around in addition to your
199.41 -> standing research contributions you've
201.359 -> been a outstanding mentor to many
203.97 -> graduate students I think you trained
205.56 -> over 60 graduate students and I think
207.81 -> you also play an important role model
211.68 -> for clinician scientists do you have any
213.989 -> advice to our aspiring clinician
216.269 -> scientists within the council of
217.739 -> hypertension yes I feel very privileged
220.62 -> to be a clinician scientist where I can
223.26 -> go from the clinic looking at or
227.629 -> consulting with patients who have real
230.489 -> problems with respect to their health
233.579 -> and particularly in my field with
235.26 -> respect to hypertension and then being
238.169 -> able to go from the clinic and ask
240.389 -> questions that I have observed or
243.81 -> generated from the clinic to the bench
246.18 -> for me this is an absolute privilege and
249.599 -> an honor to go from the clinic to the
252.09 -> bench and it's been a tremendously
256.769 -> rewarding career for me personally to
259.37 -> understand very fundamental mechanisms
263.49 -> of disease
264.73 -> then try and understand them in the
266.74 -> clinical context so a lot of my research
269.59 -> and I guess it's actually called reverse
272.74 -> translational research because a lot of
275.83 -> my research has been from fine from
278.65 -> observations in the clinic and then
281.17 -> going to the bench and dissecting out
283.42 -> some potential mechanisms that hopefully
286.06 -> we'll take back to the patient in a
288.25 -> translational way as I said being a
291.7 -> clinician scientist is a privilege and I
294.94 -> would absolutely encourage any clinician
297.73 -> who has any interest in Discovery
301.63 -> Science in wanting to understand more
305.77 -> about pathophysiology and mechanisms to
308.94 -> not be afraid and to ask those questions
311.62 -> by delving into some of the fundamental
314.8 -> science it's not easy being a clinician
317.68 -> and a scientist and one's got to manage
320.32 -> ones time very carefully but I think
323.26 -> today with a tremendous emphasis on
326.7 -> clinical research on clinician
330.04 -> scientists and especially as we move
333.28 -> forward to wanting to apply preclinical
337.03 -> discoveries to the clinic we need
338.98 -> clinician scientists and if you are
343.72 -> passionate about what you do and you
346.48 -> enjoy asking questions then going for
350.65 -> both the clinical and the basic science
353.89 -> is a perfect combination
356.32 -> I like to close by again congratulating
359.41 -> you again for being the 2019 Excellence
363.97 -> Award in hypertension research awardee
366.88 -> regice thank you so much Joey
371.27 -> [Music]
372.55 -> you
Source: https://www.youtube.com/watch?v=r6m0qz0i9Ns