Radiation induced coronary artery disease – RICAD
Radiation induced coronary artery disease – RICAD
Radiation induced coronary artery disease (RICAD) is an important long term sequelae of radiotherapy to the chest region. The most common conditions associated with RICAD are breast cancer and Hodgkin’s lymphoma. The risk is higher in Hodgkin’s lymphoma because they receive a higher dose of radiotherapy. It may be noted that radiation is used in the treatment of about 50% of cancers. Hence the importance of RICAD.
Content
0.399 -> radiation induced coronary artery
2.48 -> disease
3.52 -> ricard is an important long-term
5.92 -> sequelae of radiotherapy to the chest
8.639 -> region
9.84 -> the most common conditions associated
12.24 -> with riccard are
13.759 -> breast cancer and hot skins lymphoma
17.359 -> the risk is higher in hot skin's
19.439 -> lymphoma because
21.68 -> they receive a higher dose of
23.359 -> radiotherapy
25.199 -> it may be noted that radiation is used
27.68 -> in the treatment of about 50 of cancers
31.519 -> hence the importance of record
34.399 -> radiation causes vascular endothelial
36.719 -> injury
37.76 -> it initiates and accelerates
40.559 -> atherosclerosis
42.84 -> pro-inflammatory cytokines were
44.8 -> increased in the blood of long-term
47.36 -> survivors of atomic bomb
49.84 -> suggesting a systemic inflammatory state
53.92 -> even though record is generally more
56.32 -> common in older patients
58.96 -> younger patients have also been reported
61.92 -> one 30 year old male with radiation 15
65.199 -> years prior had total occlusion of
67.92 -> proximal left anterior descending
69.84 -> coronary artery
71.439 -> and 90 stenosis of proximal right
74.96 -> coronary artery
77.119 -> emergency angioplasty with standing was
79.52 -> done
80.479 -> another 31 year old female with
83.2 -> radiation eight years prior had left
86.32 -> ventricular dysfunction
88.32 -> ejection fraction 35 percent
91.119 -> and 99 proximal left main coronary
94.24 -> artery stenosis
96.079 -> she underwent successful coronary artery
98.4 -> bypass grafting
100.64 -> a third person was a 25 year old male
103.84 -> who had radiation for spinal tumor nine
106.399 -> years prior
107.92 -> he had left ventricular dysfunction
110.399 -> moderate iotic regurgitation
112.96 -> severe calcification of aortic wall and
115.92 -> mitral valve
117.2 -> and 99 percent left main coronary artery
120.24 -> stenosis
121.759 -> but he did not survive after coronary
124.399 -> artery bypass grafting
126.64 -> latency may be long in record with
129.52 -> patients presenting decades after
131.76 -> radiation exposure
134.04 -> manifestations range from asymptomatic
136.64 -> perfusion defects to triple vessel
139.2 -> disease and even sudden death though
142.48 -> involvement of the coronaries may be
144 -> diffused
145.12 -> a preference of proximal involvement is
147.68 -> often noted
149.52 -> inflammatory plaque with high collagen
152.08 -> and vibrant content
153.76 -> is seen
154.84 -> pathologically partial prevention may be
157.44 -> achieved by aggressive management of
160.239 -> conventional coronary risk factors
163.04 -> best initiated prior to radiation
165.519 -> therapy
167.2 -> special investigations considered are
169.84 -> stress echocardiography
171.76 -> myocardial perfusion imaging and
174.16 -> computed tomographic ct coronary
176.48 -> angiography
178.56 -> higher rates of graft failure
181.04 -> perioperative complications
183.28 -> and or cause mortality
185.36 -> are associated with coronary artery
187.44 -> bypass grafting in rickard
190.319 -> coronary angioplasty with drug loading
192.72 -> stents
193.84 -> may be the preferred option in the
195.76 -> management of rakat in most cases
199.68 -> first set of journal references
205.04 -> second set of journal references
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218.879 -> below this video
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Source: https://www.youtube.com/watch?v=QMUW93j6TY0