Fasting vs. Eating Less: What's the Difference? (Science of Fasting)

Fasting vs. Eating Less: What's the Difference? (Science of Fasting)

Fasting vs. Eating Less: What's the Difference? (Science of Fasting)

This is about the drastic physiological differences between fasting and eating less

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NOTE One of the key things in being able to fast in a healthy matter is entering the state of ketosis - that is, switching your metabolism from burning carbohydrate to burning fat. Considering most people have been burning carbohydrate their whole lives this can make fasting a challenge. Upton Sinclair recommends doing quite long fasts - 12 days, but you may want to work your way up to longer fasts. Unless you are relatively keto adapted (or have experience with fasting of course), it’s important that you take precautions while doing a fast. Fasting isn’t inherently dangerous, but diving into fasting when your body is in no way geared for it can be. I recommend doing more research before doing longer fasts. “The Complete Guide to Fasting” (http://amzn.to/2tQjxXa) is a good book to start with.
As Tim Ferriss puts it: Please don’t do anything stupid and kill yourself. It would make us both quite unhappy.

Just in case I should also say that of course you need to balance fasting with eating - You need to survive off of something. I have been doing intermittent fasting the past year (22 hours fasted, 2 hours eating - you can widen it to 16/8, which still provides great benefits) and will fast for a couple days every other month or so. Several other people have recommend a routine like this - Tim Ferriss recommends doing a 3 day fast once per month and a 7 day fast once per year.
Also make sure you’re getting enough fat, protein, micronutrients and fiber to maintain a healthy weight and healthy body - excessive fasting can be very dangerous.

Books Mentioned:
“The Obesity Code” by Dr. Jason Fung - http://amzn.to/2rXtalh
“The Fasting Cure” by Upton Sinclair - (If you google the title you can find the full book online)
“Tools of Titans” by Tim Ferriss - http://amzn.to/2rX6P7E


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Content

1 -> "Breakfast of champions."
3.701 -> What’s the difference between eating less food and eating no food?
6.13 -> Well, Let’s look at two different situations.
8.57 -> …In 1944, a study called the Minnesota Starvation Experiment was conducted and was designed
13.97 -> to understand the effects of caloric restriction on the body in order to gain some knowledge
18.34 -> that would help people starving in the aftermath of World War 2.
22.18 -> Thirty-six healthy men with an average height of 178cm (about five foot ten) and average
27.4 -> weight of 69.3 kilograms (or 153 pounds) were selected.
32.33 -> For three months, they ate a diet of 3200 calories per day.
35.71 -> Then, for six months they ate only 1570 calories.
39.899 -> However, caloric intake was adjusted to attempt to have the men lose 1.1 kilograms per week,
45.39 -> meaning some men got less than 1000 calories per day.
48.66 -> The foods given were high in carbohydrates- things like potatoes, turnips, bread and macaroni.
53.44 -> Meat and dairy products were rarely given.
56.1 -> During the six months, the men experienced profound physical and psychological changes.
60.579 -> Everyone complained that they were too cold.
62.92 -> One subject talked about having to wear a sweater in July on a sunny day.
67.3 -> The subjects’ body temperature dropped to an average of 95.8 degrees Fahrenheit (35.4
70.64 -> degrees celsius).
72.29 -> Physical endurance dropped by half, and strength showed a 21 percent decrease.
76.38 -> The men experienced a complete lack of interest in everything except for food, which they
81.29 -> were obsessed with.
82.68 -> They were plagued with constant and intense hunger.
85.67 -> There were several cases of neurotic behavior like hoarding cookbooks and utensils.
89.99 -> Two participants had to be cut from the experiment because they admitted to stealing and eating
94.38 -> several raw turnips and taking scraps of food from garbage cans.
99.47 -> At first, the participants were allowed to chew gum, until some of the men began chewing
103.75 -> up to 40 packages a day.
106.39 -> Now compare all this to the case of Angus Barbieri, a Scottish man who in 1965 fasted
111.78 -> for over 380 days straight.
114.58 -> That is he took in no food whatsoever -nothing but water, black coffee and straight tea for
118.96 -> just over a year.
120.68 -> He lost 276 pounds, going from from 456 pounds to 180.
124.6 -> A case report published by the Dundee University Department of Medicine in 1973 said “...the
130.8 -> patient remained symptom-free, felt well and walked about normally,” and “Prolonged
135.5 -> fasting in this patient had no ill-effects.”
137.98 -> There were no complaints of mind numbing hunger and he kept the weight off- for several years
142.09 -> his weight stayed around 196 pounds.
145.69 -> This of course is not a perfect comparison, with the case of Angus, there’s only one
148.98 -> subject and his starting weight was drastically higher compared to those in the Minnesota
153.79 -> Experiment.
154.79 -> However, it does illustrate some very interesting points about just how different of a physiological
159.5 -> response you get from fasting (that is, eating nothing) compared to eating less, or caloric
164.78 -> restriction.
165.98 -> Dr. Jason Fung, a Toronto physician specializing in kidney disease, and author of the Obesity
171.739 -> Code, says that compared to fasting, Caloric Reduction will result in: less weight loss,
176.83 -> more lean mass loss (i.e. more muscle loss), and more hunger.
180.83 -> Let’s start by talking about hunger.
183.58 -> In Upton Sinclair’s 1911 book “The Fasting Cure,” he writes about fasting as a means
187.83 -> to improve health.
189.21 -> In describing his first couple attempts at fasting he writes “I was very hungry for
192.94 -> the first day-the unwholesome, ravening sort of hunger that all dyspeptics know.
197.6 -> I had a little hunger the second morning, and thereafter, to my great astonishment,
201.8 -> no hunger whatever-no more interest in food than if I had ever known the taste of it.”
207.129 -> Sinclair recommends to do quite long fasts - around 12 days or so.
211.31 -> In a section addressing concerns about fasting he writes “Several people have asked me
215.099 -> if it would not be better for them to eat very lightly instead of fasting, or to content
219.519 -> themselves with fasts of two or three days at frequent intervals.
223.25 -> My reply to that is that I find it very much harder to do that, because all the trouble
227.299 -> in the fast occurs during the first two or three days.
230.09 -> It is during those days that you are hungry.”
233.61 -> Then he says: “...perhaps, it might be a good thing to eat very lightly of fruit, instead
237.68 -> of taking an absolute fast-the only trouble is that I cannot do it.
241.709 -> Again and again I have tried, but always with the same result: the light meals are just
245.65 -> enough to keep me ravenously hungry...”
247.96 -> In the book he says you will know when you should finish fasting, because your hunger
251.22 -> will “return.”
252.97 -> He quotes a letter he received from a 72 year old man saying “After fasting twenty-eight
257.47 -> days I began to be hungry, and broke my fast with a little grape juice, followed the next
262.47 -> day with tomatoes, and later with vegetable soup.
265.06 -> ”
266.06 -> He quotes several other letters he received from readers and this disappearance and reappearance
269.6 -> of hunger is a common theme.
271.8 -> Everyone who wrote to him fasted for at least 10 days, saying they only broke their fast
276.009 -> when hunger “returned.”
278.53 -> This phenomenon runs contrary to the idea one would get hungrier and hungrier as long
283.09 -> as they don’t eat.
284.639 -> However, most people have experienced for themselves that this is not the case.
288.52 -> Some will find that they are not hungry at all in the morning or at least they are not
292.1 -> as hungry as they are for lunch or dinner.
294.8 -> But unless you are eating in your sleep, the morning is when you have gone the longest
298.47 -> without food.
300.62 -> Some of this can be explained by the hormone Ghrelin.
303.28 -> Ghrelin, known as the “hunger hormone” has been found to increase appetite and weight
307.83 -> gain.
308.83 -> A study at the Medical University of Vienna looked at patients participating in a 33 hour
313.431 -> fast.
314.78 -> Their ghrelin levels were checked every 20 minutes.
316.94 -> Here’s how the levels changed over time.
320.09 -> What’s interesting is ghrelin is lowest at 9:00AM, which is when they have gone the
324.99 -> longest without eating.
326.509 -> And, Ghrelin comes in waves and overall doesn’t rise during the period the subjects were fasting.
332.36 -> Then, As you can see, ghrelin rises in sync with normal lunch and dinner times, as if
336.96 -> the body had learned to expect food at that time.
339.94 -> However, that ghrelin rise spontaneously decreases after 2 hours without food.
345.31 -> I’ve experienced this kind of spontaneous decrease in hunger myself many times when
349.61 -> I was working as a consultant.
351.62 -> Lunch time would come and I would be hungry, but I was too busy to eat so I just kept working.
356.4 -> Pretty quickly I forgot about eating and wasn’t particularly hungry until dinner time.
361.139 -> This is very helpful to keep in mind if you’re doing a long fast or even if you’re starting
364.979 -> intermittent fasting - you’re going to get annoying waves of hunger, especially around
369.419 -> the times that you usually eat.
370.91 -> But, it won’t get worse, the hunger will simply go away if you are patient.
376.68 -> Another study concerning ghrelin was done at Aarhus University Hospital in Denmark and
380.949 -> it shows what happens if you do a longer fast.
383.59 -> They looked at the ghrelin levels of 33 subjects who fasted for 84 hours.
387.71 -> So, did they get increasingly hungrier throughout the fasting period?
391.13 -> Well, No.
392.21 -> Their ghrelin followed similar rhythms each day but actually decreased the longer they
397.569 -> fasted.
398.569 -> Going longer without food actually made them less hungry.
402.59 -> This gives credence to what Upton Sinclair and his readers said about hunger disappearing
406.13 -> after the first 3 days of fasting.
407.99 -> I’ve done a couple 5 and 6 day fasts in the past myself and this was indeed the case.
412.819 -> Actually, I did a 4 day fast last week and again the 4th day was when I had the least
418.37 -> hunger.
419.75 -> Another thing that may be contributing to this phenomenon is that you are entering ketosis.
424.949 -> Ketosis is a physiological state where your metabolism switches to using primarily fat
429.3 -> for energy.
430.3 -> For this reason ketosis is popular as a weight loss method, but it has many other benefits
435.039 -> including better physical and mental efficiency.
438.85 -> Ketosis occurs when you restrict carbohydrates down to 50 grams or less and you don’t eat
442.63 -> too much protein.
443.93 -> Everyone’s body is a bit different so you might have to eat even less carbohydrate or
448.11 -> may have room for more, but the recommended ratio of a ketogenic diet is to get 5% of
452.59 -> your calories from carbs, 25% from protein and 75% from good fat.
457.75 -> A simpler way to enter ketosis is just don’t eat anything for a long enough time.
463.19 -> This is one of the major points in the difference between fasting and caloric restriction.
467.52 -> The problem with the subjects in the Minnesota Starvation experiment was that they were eating
471.25 -> just enough to keep them out ketosis and keep their metabolism primed for burning carbohydrate
476.389 -> (glucose), so they couldn’t use their body fat for energy.
480.349 -> This explains a lot of things like why they were losing their strength and were very sluggish
484.44 -> and cold.
485.72 -> It also clears up why Upton Sinclair said fruit or light meals were just enough to keep
489.639 -> him ravenously hungry and far weaker than if he had just eaten nothing.
495.319 -> As I explained in my last video, insulin is necessary for glucose to get into the cell
499.72 -> to be used for energy.
501.31 -> When you eat carbohydrates, the pancreas secretes insulin to deal with it and too much insulin
506.039 -> hampers the action of something called hormone sensitive lipase which is necessary to mobilize
511.71 -> fat and use it for fuel.
513.82 -> Though, keep in mind that grains or refined carbohydrates will provoke a much higher insulin
519.06 -> response than say green vegetables.
522.5 -> Now because the body is having a hard time using its fat for fuel, it will do a couple
527.32 -> things: One, it will simply slow down metabolism to preserve energy.
532.32 -> In the Minnesota Starvation experiment, the subjects metabolism dropped by 40 percent.
537.58 -> Their bodies didn’t have access to its stored energy, and their restricted calorie diets
541.87 -> don’t provide much fuel so there’s no choice but to slow down the metabolism.
546.87 -> Ironically, in the case of fasting, as Jason Fung points out - metabolism actually goes
551.69 -> up.
552.69 -> "If you don't do anything about your insulin and just reduce your calories, your metabolism
557.01 -> goes down.
558.01 -> But what happens during fasting?
559.98 -> Well, here's a study of 4 consecutive days of fasting.
564.63 -> What happens to your REE - this is this middle line here, that's the resting energy expenditure.
570.62 -> It doesn't go down, it goes up.
574.84 -> You're burning more energy than you did."
578.93 -> The other thing the body will do when it can’t use fat for fuel is break down muscle into
583.68 -> glucose through a process called gluconeogenesis.
587.24 -> The body doesn’t want do this too much because it’s not very smart to completely eat through
590.83 -> something as important as muscle, but when it can’t access its own stored energy it’s
596.18 -> more likely to resort to this.
598.44 -> This is why you’ll experience more muscle loss on caloric restriction than if you ate
602.61 -> nothing.
604.45 -> When you are fasting, Human Growth Hormone is released.
608.22 -> As the name implies, Human Growth Hormone is an anabolic hormone - a hormone conducive
612.7 -> to growth.
614.3 -> In Leningher’s Principles of Biochemistry textbook they give the example of how injecting
618.81 -> the human growth hormone gene into a mouse makes it unusually large.
624.13 -> As explained in Guyton’s Textbook of Medical Physiology: "...growth hormone also mobilizes
628.959 -> large quantities of free fatty acids from the adipose tissue, and these in turn are
633.26 -> used to supply most of the energy for the body cells, thus acting as a potent "protein
638.649 -> sparer."
639.649 -> "That is human growth hormone is protecting your muscles from breaking down.
644.81 -> The study I referred to earlier about subjects undergoing an 84 hour fast shows that growth
649.35 -> hormone rises significantly after the second day of fasting.
655.54 -> As mentioned earlier, you should enter ketosis sometime within the first 3 days or so of
659.839 -> fasting, and it depends on how much you are moving around and what your diet was like
664.089 -> before starting the fast.
665.87 -> The state of ketosis is a great indicator that your body is making good use of its stored
670.97 -> body fat for energy.
673.079 -> In Tim Ferriss’ book “Tools of Titans,” Tim talks about his first clinically supervised
678.03 -> 7 day fast.
679.6 -> For some sort of liability reasons, he wasn’t allowed to exercise or leave the facility.
684.91 -> Considering exercise is a potent stimulator of human growth hormone and will help deplete
689.07 -> glucose stores, not getting any exercise is a great way to prevent yourself from getting
693.63 -> into ketosis during a fast.
695.85 -> It’s also a great way to lose muscle.
698.399 -> Tim says he lost 12 pounds of muscle during the overly restrictive clinically supervised
703.69 -> 7 day fast.
704.88 -> But, when following a protocol designed to get him into ketosis as soon as possible - involving
709.51 -> things like 4 hours of brisk walking, he did a ten day fast and apparently lost zero muscle
715.029 -> mass.
716.68 -> One last factor in Ketosis preserving muscle is leucine.
720.389 -> When you're in ketosis, you have a higher fasting blood leucine level.
723.99 -> And leucine is a key branch chain amino acid that has an anabolic effect on the body so
728.91 -> it preserves lean body mass.
730.97 -> A lot of people interested in building muscle may be worried that fasting or a ketogenic
735.48 -> diet wouldn’t work for them because insulin and therefore carbohydrates are necessary
739.86 -> for protein synthesis (i.e. muscle growth), but actually this leucine fills that role
745.99 -> and is a good trigger for protein synthesis.
748.2 -> So, just to sum all this up: compared to a conventional calorie restricted diet, fasting
754.051 -> means you lose more weight in the form of fat, you keep more muscle, you have more energy,
759.62 -> and you are less hungry . If proper weight loss is your goal, it might be better to eat
764.141 -> nothing at all rather than eating a conventional low calorie diet.

Source: https://www.youtube.com/watch?v=APZCfmgzoS0