What is Peripheral Artery Disease (PAD): Causes and Consequences
What is Peripheral Artery Disease (PAD): Causes and Consequences
Peripheral Artery Disease (PAD) is a progressive, systemic disease resulting from the formation of atherosclerotic plaques in the peripheral arteries, causes stenosis and occlusion, more details at more details at https://www.thrombosisadviser.com/en/…
PAD is often asymptomatic, but severe vascular obstruction can lead to limb ischaemia requiring amputation. Despite treatment involving antiplatelet therapy and lifestyle changes, patients with Peripheral Artery Disease (PAD) are still at high risk of thrombotic events.
Approval Number: G.MKT.GM.XA.08.2017.1695
Content
3.74 -> Up to 16% of people over the age of 55 suffer from peripheral artery disease, or PAD.
11.2 -> Risk factors for the condition include diabetes, smoking, older age,
16.62 -> and atherosclerosis in any arterial blood vessel.
20.92 -> PAD is a progressive condition caused by the formation of atherosclerotic plaques
25.88 -> in the peripheral arteries, reducing blood flow and, in some cases, causing pain.
31.28 -> The rupture of one of these plaques triggers platelet activation and Factor Xamediated thrombin generation,
38.02 -> leading to the formation of a blood clot, a process known as atherothrombosis.
43.34 -> This further limits – or may even completely block – blood flow through the artery,
48.2 -> causing symptoms to worsen. Vascular obstruction may cause limb ischaemia
53.06 -> which, in the most severe cases, can lead to limb amputation
58.36 -> Importantly, PAD is frequently asymptomatic.
62.54 -> More than half of patients undergoing major amputation
65.68 -> for critical limb ischaemia may have had no symptoms of ischaemia as little as six months earlier.
71.82 -> In some high-risk cases, revascularization is recommended to relieve the ischaemia.
78 -> This involves using a stent to manually widen the artery and restore blood flow.
84.14 -> Over 60% of patients with PAD also have atherosclerotic plaques in the coronary arteries of the heart
90.92 -> or in the arteries supplying oxygen to the brain.
94.48 -> Patients with PAD are therefore not only at risk of critical limb ischaemia,
98.74 -> but also of other thrombotic events such as myocardial infarction or stroke.
104.64 -> Arterial blood clots are rich in platelets. Guidelines recommend that patients with PAD
110.68 -> receive antiplatelet agents and make certain lifestyle changes to reduce their atherothrombotic risk.
117.52 -> Despite this, patients remain at high risk of thrombotic events.
121.34 -> In one clinical trial, nearly 1 in 10 patients with previous PAD had a myocardial infarction,
127.5 -> stroke or died of cardiovascular causes, despite receiving acetylsalicylic acid.
133.66 -> To further reduce this risk, clinical trials are investigating optimal treatment strategies
138.86 -> in patients with acute limb ischaemia or stable PAD.
142.5 -> The results of these studies hold great interest for physicians and patients alike.
Source: https://www.youtube.com/watch?v=5yArc6oTmeQ